A simple, accurate, precise, rapid and bathochromically shifted UV spectrophotometric method has been developed using phosphate buffer (pH-12.2) and methanol (for solubility purpose) to determine the nateglinide in bulk and tablet dosage formulations. At bathochromically shifted λmax from 209 nm to 214.7 nm, it was proved linear in the range of 10 – 60 mg/ml and exhibited good correlation coefficient (r2 = 0.9995) and excellent mean recovery (98.58 – 100.02%). The limit of detection (LOD) and limit of quantitation (LOQ) were found to be 1.12 μg/ml and 3.41 μg/ml respectively. The method was validated statistically and satisfactory values of percent relative standard deviation for system and method precision indicated that the method was precise.
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